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KMID : 0869220200240010037
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Journal of Korean Geriatric Psychiatry
2020 Volume.24 No. 1 p.37 ~ p.41
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Decreased Hippocampal Metabolism in Amnestic Mild Cognitive Impairment: Positron Emission Tomography Study
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Park Chan-Hum
Lee Young-Min
Park Je-Min
Lee Byung-Dae
Moon Eun-Soo
Jeong Hee-Jeong
Kim Soo-Yeon
Lee Kang-Yoon
Suh Hwa-Gyu
Park Hye-Kyung
Kim Hak-Jin
Park Kyoung-June
Mun Chi-Woong
Chung Young-In
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Abstract
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Objective: Little is known about factors influencing of hippocampal metabolism (HM) in mild cognitive impairment (MCI). Our objective was to determine whether HM in patients with amnestic MCI (aMCI) is decreased than non-amnestic MCI (naMCI).
Methods: Overall, 32 MCI patients underwent 18F-fluorodeoxyglucose-positron emission tomography. They were characterized as aMCI (n=18) or naMCI (n=14) according to comprehensive neuropsychological criteria. Analysis of variances were used to assess differences on HM between aMCI and naMCI after controlling age, sex, education and Korean version of Mini Mental Status Examination.
Results: We found that HM was more decreased in aMCI than naMCI. This result was not changed after controlling hippocampal volume.
Conclusion: Our findings suggest that aMCI is associated with decreased HM in MCI.
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KEYWORD
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Amnestic mild cognitive impairment, Hippocampal metabolism, Hippocampal volume
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